Volume 3, Issue 1, Autumn 2007, Page 1-307


Positive Anti-neutrophil Cytoplasmic Antibodies (ANCA) as a function of Human Leukocyte Antigens (HLA) in Inflammatory Bowel Disease

Hummady AL-Hilaly

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 11-22

The newly described distinct associations of HLA class I and II genes with ulcerative colitis (UC) and Crohn's disease (CD) provide strong evidence for genetic heterogeneity of susceptibility between these two major forms of inflammatory bowel disease (IBD), moreover, the familial distribution of anti-neutrophil cytoplasmic antibodies (ANCAs, a subclinical markers) in patient's families has further implicated the existence of heterogeneity within this disease. To test the hypothesis that heterogeneity indicated by ANCAs has a genetic basis that resides within HLA region, we studied 42 IBD Iraqi cases (30 UC and 12 CD) and an ethnically matched healthy control group (n=35). Microlymphocytotoxicity test was used for classes I and II HLA-typing. ANCAs were detected using an ELISA test. It was observed that controls were all p.ANCA-negatives, while 25 (83.3%) and 4 (33.3%) of UC and CD, respectively, were positives for this test. Only 7 (8.57%) of controls were c.ANCA positives, while 7 (23.3%) and 2 (16.6%) of UC and CD patients were positives, respectively. P.ANACA-positive IBD patient's status was reported to be positively associated with the frequencies of A11, DR2, DQ1, and DQ2 revealing etiology at the respective EFs : 0.151, 0.185, 0.241, and 0.215. In contrast, B12, Cw4, and DR1 were conferred preventive roles (p.ANCA negatives) at significantly decreased frequencies of IOR; 16.2, 7.3, and10.6, respectively, in addition to DR4 and DQ3 which appeared to have similar roles. On the other hand, A11, A(28+34), and Cw6 were observed in positive associations with c.ANCA-positive patients at respective EFs: 0.342, 0.229, and 0.326. Whoever, no allele was detected to prevent the positivity of this test. Thus, genetic HLA-based heterogeneity has been concluded within ANCA positiveANCA-negative IBD patients.

A histopathological study of the umbilical cord of the pregnant women infected with the pregnancy diabetes

Wasan Abdul Wahab; Noah Shaker AL-Badry; Salem Rashid AL-Abady

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 1-10

Ahisttopathological study for samples of umbilicals cord from a group of the women infected with pregnancy diabetes competed with for samples of umbilical cords of group of the women that have a healthy pregnancy and considered as (control). Morphometic method has been used with using ocular lens for measuring the diameters of the blood vessels (arteries and veins) of umbilical cord and its thickness. The results have shown an increase in the thickness of the umbilical cord in general, and increasing in thickness and size of the walls of the two vessels and inflation in the endothelial tissues and its hyperhistogenesis with a narrowness in the cavity opening size of the umbilical vessels (artery,vein).

The modifiable risk factors of hypertension in youths

Riyadh Dh. Mehdi Al-Zubaidi

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 23-27

Objective: To verify the modifiable cause(s) of hypertension in youths. Method: It is a prospective observational study, it was done in out patient private clinic in Kerbala city during the period between May 2004 and October 2006 .three hundred and fifty persons were included, the ages of all persons ranged between 20 and 35years, but 236 were hypertensive and 114 were normotensive.The main parameters that were studied included; body mass index (BMI) ,total serum cholesterol and smoking. Results: All the hypertensive patients belong to families with history of hypertension, 80.5% of them were hypercholestremic,64.4% were obese and 53.8% were smoker. On the other side, only 21% of the persons of the normotensive group belonged to families with hypertension , none of them were obese, but 7.9% were hypercholestremic and 13.1% were smoker. Conclusion: hypercholestremia,obesity and smoking are a modifiable causes of hypertension in youth. Early recognition, education and treatment of hypercholestremia plus weight reduction and cessation of smoking may prevent or reduce the severity of hypertension and hence its hazardous complication later on.

X-ray examination to measurement radiation doses of patients in three Erbil hospitals

Runak Tahr Ali

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 28-40

Thermo luminescent dosimeters (TLDs) have been used to measure the entrance surface doses (ESDs) of patients undergoing pelvis, abdomen and lumbar spine diagnostic X-ray examinations in Erbil. A total of three public hospitals and 171 patients were included in this investigation. The ages of the patients involved were from 40 years to 85 years, while their weights ranged from 64 kg to 73 kg. Mean, of ESDs are reported. The results showed that in most cases, for each of the examinations, the individual ESD values are found to be comparable with, and higher than, those from Ghana and Tanzania, respectively. The ranges found in this work are high and this indicates more attention needs to be given to X-ray facilities in the country. This also suggests that radiographic departments need to review their radiographic practices in order to bring their doses to optimum levels. Effective doses were also calculated from the ESD values. The radiographic parameters used for all the patients were also compared with the European criteria. It is recommended that the tube filtration at one hospital be increased. The importance of good regulatory activities and trained personnel is stressed in this work. Apart from the fact that the data provided in this work will be useful for the formulation of national guidance levels, they also provide patient dosimeter information on healthcare level countries.

Delayed Arrival of Stroke patients to the Hospital

Kfah K. Al- Ubaidy

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 41-51

Background:
Although recent advances have been made in the treatment of acute stroke, patients often arrive at the hospital too late to receive the maximum benefit from these new therapies.


Objective:
To investigate factors that influence the time from symptom onset to hospital arrival (delay time) for patients with stroke. .
Methods:
Prospective observational study by recording the patient's characteristics, final diagnosis, and admission delay for all suspected acute stroke admitted patients within 3 days of onset.
Results:
246 stroke patients were studied at Al-Dewania teaching hospital, the median age of the patients was 63 years, 125 were male. The median delay time was 11.6 hours, 6.1% of patients arrived within 3 hours, 18.3% were arrived within 6 hours., Middle age ,male , first stroke ,mild neurological deficit, living in rural areas ,abscess of ambulance transport and low medical public knowledge of stroke significantly delay time of presentation to the hospital.
Conclusion:
Increase public awareness of stroke symptoms and the need to seek early medical attention with direct transport to the hospital better by ambulance will be required for effective treatment of acute stroke.

EFFECTS OF CELECOXIB AND ROFECOXIB ON NEUTROPHILES AND LYMPHOCYTE COUNTS IN RATS (COMPARATIVE STUDY)

Adel. H. Sheeh

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 52-61

Non steroidal anti-inflammatory drugs NSAIDs one of the most commonly used drugs all over the world specially for treatment of chronic disease their effect on immune system should be considered in selection of member of non steroidal anti inflammatory drug The objective of this study is to determine whether Celecoxib and Rofecoxib are associated with a lower incidence leucopenia
Thirty (30) Sprague-Dawely male rats were used during this study . The animals were divided in to three groups : group 1 –Control , group 2 received Celecoxib and group 3 received Rofecoxib for 1 month duration .Samples of blood before and after treatment were taken for determination of total W.B.C , neutrophiles and lymphocyte counts. The results were as fallow:
1-Celecoxib 15 mg/kg/day and Rofecoxib 10 mg/kg/day caused significant reduction in total W.B.C , Neutrophiles and Lymphocyte counts .
2-Rofecoxib 10 mg/kg/day caused the less reduction in total W.B.C. count, neutrophiles and lymphocyte counts as compared with Celecoxib 15 mg.kg.day/ day

The frequency of ophthalmia neonatorum in hospitalized neonates and newborn babies delivered in the maternity and children teaching hospital in Diwaniah

Najlaa Abdullah Dawood; Adnan Hamad Al-Hamdani; Mohammed Mojar Al-Shamsi

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 62-70

Objectives:
Determine the frequency of ophthalmia neonatorum among hospitalized neonates and those delivered in the labor room and operation theatres in the maternity and children teaching hospitals in Diwaniah in addition to determination of the causative microorganisms and their antibiotic sensitivity.
Materials & methods:
Two hundreds seventy conjunctival swabs were collected randomly from neonates admitted to the septic and aseptic neonatal care units and newborn babies delivered in the labor room and operation theatres in the maternity and children teaching hospital Diwaniah during the period from September 2002 to February 2003.
Results :
The clinical and microbiological diagnosis of ophthalmia neonatorum was made in 190 neonates ( 70.3 % ) , 154 cases were due to Gram positive bacteria ( 84.6 % ) and 28 were due to Gram negative bacteria ( 15.4 % ) , six cases were due to Candida . Most infections were in neonates aged 1- 5 days . Gram positive bacteria were sensitive to Cefotaxime and resistant to Amikacin , while Gram negative bacteria were sensitive to Tetracycline.
Discussion :
The results were presented and compared with other studies and concentration on epidemiological and microbiological issues was made.
This article is derived from M Sc Thesis submitted by mrs Najlaa Abdullah in partial requirements for the degree of M Sc in Microbiology 2004

The effect of aqueous and alcoholic extracts of fruit pell of Punica granutum against Leishmania major in vitro and in vivo

A. H. Jassim; H. M. Jarallah; A. H. H. Awad

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 71-84

The effects of aqueous and alcoholic extract of Punica granatum, were studied against the activity and growth of promastigote of Leishmania major in vitro. The alcoholic extract was used by topical route against BALB/c mice infected with L.major.
The alcoholic extract showed high activity against L.major promastigote than aqueous extract.

The Effect of Methyl dopa on serum lipid profile in rat

Laith Mohammed Abbass AL-Hussueni

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 85-92

Evidence liking hypertension and dyslipidemia are very important in deciding which antihypertensive drug is going to be describe to hypertensive patient who had or at risk to had dyslipidemia. Antihypertensive drugs which have neutral effect or preferably beneficial effect on lipid profile are the first choice in those patients. Drugs with harmful effect on serum lipid profile may add another problem to the patient and increase the risk of complications.


Purpose:
This study is carried on to evaluate the effect of methyl dopa on serum lipid profile.
Methods:

Twenty rats enrolled in the experiment given atherogenic diet for twelve weeks then randomly divided into two groups, first group received 33 mg /Kg /day P. O Methyl dopa dissolved in 2 ml distilled water given by nasogastric tube twice daily and serve as central group. The treatment continues with atherogenic diet for another twelve weeks. The serum lipid profile namely triglyceride, total cholesterol, LDL-cholesterol (low density lipoprotein cholesterol) HDL-cholesterol (high density lipoprotein cholesterol) and HDL-cholesterol / total cholesterol ratio were estimated before and after the treatment. The statistical analysis was done using ANOVA with level of significance P<0.05.
Result:

Methyl dopa was found to have no effect on serum triglyceride level and on total cholesterol serum level but it causes significant decrease in LDL-cholesterol serum level and significant increase in HDL- cholesterol serum level in comparison to control group.
Conclusion:

Methyl dopa has beneficial effect on serum lipid profile as it causes decrease in LDL-cholesterol level which is the atherogenic portion of cholesterol and causes increase in HDL-cholesterol level which is the protective portion of cholesterol. This effect justify it's use in patients who have or at risk to have dyslipidemia.

Bacteriological and Serological Study of Beta Hemolytic Streptococcal Throat Infection Among School Children In Najaf Governorate

Israa K. AL-yasiri; Jafaar K. AL- Mouswi

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 93-102

The study presents the findings of bacteriological and immunological examinations of (250) children suffering from throat infection and (350) school children without throat infection as control .one hundred and five (105)infected children and one hundred (100) uninfected children were selected for asessment of ASO titer and CRP level. It was found that group A beta-hemolytic streptococci, a known sore throat pathogens, were


significantly detected more often among children with throat infection than

among healthy carriers as controls (43.6 % versus. 26 %) respectively. Also there was significant difference (p<0.005) between infected children and healthy carriers in isolation rate of group C beta-hemolytic streptococci (16.4 %vs. 8.95 %) respectively.
The study indicated that there was significant difference in ASO value 1/200 IU/ml between infected children (57.2 %) and controls (4 %)as well as there was significant relationship between ASO positivity and beta-hemolytic streptococci carriage.
There was significant difference in CRP value between infected children (94.3 %) and controls (20 %). the sensitivity and specificity for ASO test was 57 %and 96 % respectively and for CRP test was 94.5 % and 80 % respectively.

The Effect of Recasting on the Castability of Prepared Nickel-Chromium Dental Base-Metal Casting Alloy

Suhad Jabar Hemed; Mohammed Talib Al-khafagy

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 103-111

Background:
Evaluation the effect of recasting process on the castability value of prepared Ni-Cr dental base-metal casting alloy and compare it with other conventional alloy.
Materials and methods:
The prepared Ni-Cr alloy was locally prepared in Iraq by Al-Khafagy (2003), while the CB Blando Ni-Cr was used as conventional alloy. A wax mash of 1mm opening and (10*10) segments square was invested in phosphate-bonded investment and casted by using induction casting machine. The number of complete cast segments was counted, divided by (220) and multiplied by (100) to obtain a percentage designated the castability value (Cv).
Results and discussion:
The prepared Ni-Cr alloy samples were showed lower castability values than the conventional alloy, this may be related to unalloyed silicon and manages and loss the role of these elements in improvement of castability of prepared Ni-Cr alloy. The castibility value was decreased as the percentage of used alloy increased, however, ANOVA test revealed a non significant differences within the groups. Practically, the experimental and conventional alloys could be recastd if the recasted process will not affect the other properties of such alloys.

Prevalence of hyperuricemia in diabetes mellitus

Mohammed abdul Hessein

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 119-127

Objective :
To explore the prevalence of hyperuricemia in diabetes mellitus patients.
Design :
Eighty diabetic patients attended diabetic clinic center at teaching hospital in Najaf city between February and June 2006 were evaluated to explore the prevalence of hyperuricemia , thirty of them ( group A ) had joint
problems and fifty of them (group B) did not.
Result:
Ten patients (33%) from group A had hyperuricemia versus one (2%) from group B.
Conclusion:
Data from observation study suggest that there is correlation between joint problems and high serum uric acid in diabetes mellitus .

Frequency Of Sexual Dysfunction In Treated and Untreated Depressed Male Patients

Saadoun Dawood Ahmed AL-Jiboori

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 128-138

Objective: Morbidity of depression is not restricted to affective changes, but touches many aspects of psycho-physiological function. One of the most important of these is sexual function. Sexual dysfunction is common among individuals with major depressive disorder.
Aim of the study: To compare the frequency and type of sexual dysfunction in depressed patients prior to medication and subsequent to the medication.
Method: The sample of the study included 300 consulting male patients attending psychiatric unit in Azdi general hospital ,150 patients of them were on antidepressant medication and 150 of them without medication. Another 150 patients attending general male outpatient department acted as normal controls. We used symptoms checklist of the Diagnostic and Statistical Manual of mental disorders, 4thedition (DSM-IV), criteria for major depression in order to ascertain the diagnosis. Depression severity was rated using the Hamilton Depression Rating Scale(HAM-DRS). Patients sexual function was assessed using Arizon Sexual Experience Scale(ASEX) for men.
Results: The levels of libido reported by the depressed patients (55%) differ significantly from normal controls (10%). Patients taking antidepressant medication reported Erectile Dysfunction (52%), Ejaculatory Dysfunction (48%) and Orgasmic Dysfunction (30%) significantly different from untreated depressed patients (20%),(18%),(13%)respectively.
Conclusion: Sexual dysfunction was prevalent in depressed male patients.

Acomparative study of Depression among patients with hip fracture With psychiatric depressive patients

Mossa O. Mossa Al-gazali; Ihssan abdul abbas; Abdul zahra al-khafagi

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 139-145

A total (50)patients with hip fracture, admitted to the Al-Diwaniya teaching hospital were screened for the depression and those fitting the criterion for the depression were studied further.
32% of the patients with the hip fracture met the criterion for the depression based on DSMIV. (1)
The occurrence of depression and course appeared closely bound up with hip fracture, when compared with depression in (100)psychiatric depressed patients, the hip fracture depressed patients were less severely depressed, less guilty feeling and suicidal, but show sever anxiety, refamdation and helplessness

Objectives
To determine the prevalence of depression among the patients with fracture around the hip compared with psychiatric depressed patients.

PERIPATUM CARDIOMYOPATHY ; FIVE YEARS STUDY IN DIWANIYAH TEACHING HOSPITAL

Mohanad Al-Jashami

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 151-156

Objective: Astudy was carried out to verify peri partum cardiomyopathy (PPCMP) frequency among other cardiomyopathy (CM)
Patients and methods : From April 2001 to April 2005 , out and in patients (98) patients with clinically unexplained congestive heart failure had been subjected to careful echocardiographic study.
Results : it was found that (13.2%) of dilated CM studied had PPCM. All the 13 patients of PPCM were multiparous ; had heart failure in stage 111-1V; and they were anemic and underweight.

The Prevalence Of Congenital Heart Diseases Among Down's Syndrome Children In Diwaniyah Governorate

Mohanad Al-Jashami

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 157-164

Objective :A survey was carried out to assess the prevalence of congenital heart diseases (CHD).
Patients And Methods: among (180) Down's syndrome (DS)children in institute for mentally handicapped (Alraga institute) and outpatients referred for ECHO study in Diwaniyah Teaching Hospital.
REULTS: It was found that (61.1%) of DS cases studied had CHD with a M:F ratio of 1.5:1. The commonest type of CHD found was ventricular septal defect (VSD), followed by atrial septal defect (ASD), mitral valve prolapse(MVP), tetralogy of fallot (TOF), ,patent ductus arteriosus (PDA) and co-arctation of aorta in (54.5 %, 17.2 %, 14.5 %, 11.8 %, 0.9%, 0.9% respectively). The most common mode of presentation of CHD was recurrent chest infection. It was found that about 17.5% of cases with VSD had spontaneous closure, while only (7.5%) were treated surgically. The rest are left untreated.

Unilateral Perthes, Disease;A Study of the unaffected hip joint

Mossa O. Mossa Al-gazali

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 165-169

Objective: To asses the epiphyseal development of the unaffected hip in unilateral perthes disease. Patients and methods; Thirty two patients with unilateral perthes disease,their normal unaffected hip joints compared with forty normal children regarding their ossification of the proximal capital femoral epiphysis over aperiod of two years . Results; The epiphyseal height of the normal hip in unilateral Perthes disease was less than for the normal children (compared group).Conclusion;Delay in ossification of the proximal head may be one of the risk factors for Perthes disease.

Skin Infections in Patients with Diabetes Mellitus : a case-series study

Nasam Emad; Qabas Natheer; adA.Faza; Sua

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 170-177

This study was designed to evaluate skin infections in 72 diabetic patients who consulted the department of dermatology in Al- Diwaniya hospital in Al-Diwaniya city collected during the period form June 2006 until may 2007 . A total of (72) patients suffering from cutaneous disorders were seen.
Full information were obtained from each patient using special questionnaire sheet . The rate of pathogenic microorganisims isolated from 72 patients was ( 66.6% ). The highest rate of microorganisms among patients was fungi 24 (50%) ; followed by bacteria in 21( 43.7% ) ;other causes 11 ( 6.2% ).
The highest rate of fungi was Tinea pedis (54.1%) followed by Candida albicans (37.5%) ; Tinea cruris (4.1%) Tinea corporis (4.1%) . Among bacteria the highest rate was Staphylococcus aureus (9.80%) ; followed by Strebtococci sp. (14.2%) , whereas Klebsiella sp. , Proteus sp. were (4.7%) ,(4.7%) respectively .
The peak age of incidence was (40-60) years ,it was found that male are more then females and type 2-Diabetic patients more than type 1- Diabetic patients .

Invasive lobular carcinoma versus duct carcinoma of the breast

Shoroq M.Abbas Al-Temimi

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 178-184

Lobular carcinoma of the breast uncommon compared to duct carcinoma .77 specimens with breast carcinoma in the Diwania teaching hospital were examined in the period from feb.2000 to feb.2006.Thirteen out of 77 specimen were proved to be invasive lobular carcinoma of the breast and out of these 13 specimen 5 were from a patients with bilateral disease and two specimen proved to be lobular carcinoma insitu.All the specimen were examined for multifocality and compared with duct carcinoma.
Aim of this study
To confirm that invasive lobular carcinoma present bilaterally and it is multifocal

Management of fistula-in-ano - a common clinical problem

Nahidh R. Alammar

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 185-194

A prospective study of 54 patients (age ranging from 18-54 years) operated for perianal fistula.These operations done in al- Diwanyiah teaching hospital and private hospital in period from: January 2003 to July 2005.To determine the incidence of low or high anal fistula, recurrence rate following surgery and effect of surgery as well as effect of previous procedures on the incontinence. The fifty four patients (54) were subdivided into two groups’ i.e. low and high anal fistulae and were operated by laying open technique (fistulotomy) for low fistulae and by two-stage fistulotomy, seton “cut-through technique and Re-routing of the tract for high fistulae.
Patients were followed to see the incidence of recurrence, effect of surgery on continence as well as effect of previous surgery on continence. Overall recurrence was only 4.44% for low fistulae and 11.11% for high fistula in-ano. Minor incontinence was observed only following surgery for high variety. No such complication occurred in low variety.
Low fistulae can be laid open with minimal loss of sphincter muscle but as for as the high variety is concerned it is safer to place a seton or stage the procedure.

Epidemiologic Study of Opportunistic Fungi Contaminating Soil of Schools, Mosques and Hotels in Diwaniya City - Iraq

Rana S. Jabbar; Mohammad A.AL-Shammary; Adnan H AL-Hamdani

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 195-208

Soil mycoflora in several schools, mosques and hotels in Diwaniya city were examined using dilution plate technique and three different culture media with and without supplementation of cycloheximide antifungal. A total number of fungal isolates observed in all experiments were 2589 that represent 57 species related to 48 genus, in addition to the white and dark sterile mycelium.
Cycloheximide substantially affected the frequency of isolated fungi. Where Penicillium chrysogenum was the most frequent species (44.73%) on culture media free from cycloheximide. Acremonium kiliense was the most frequent one (26.85%) on media supplemented with this antifungal. In contrast the frequency and occurrence of P. chrysogenum in both soils of school (41.26%) and (95.95%) respectively and of mosques (43.63%) and(100%) respectively was higher than other species, also this species was the most occurring (90%) in hotels soil. Memoneilla subimplex was the most frequent species (18.87%) in this soil.
Number of isolates were varied according to the addition of cycloheximide and the composition of culture media: highest number of fungal isolates (337) were recorded when potato dextrose agar used, in contrast the greatest numbers of fungal species (21) were identified when sabouraude dextrose agar was used. In culture media free of cycloheximide the number of fungal isolates and fungal species were substantially increased to 720 and 37 respectively.
The results of this experiment revealed a negative correlation between soil fungi and pH ( as r= 0.307 with fungal isolates and 0.185 with the number of fungal species ) while this correlation was positive with organic content of soil salinity (r= 0.042 and 0.130 with fungal isolates and fungal species respectively ) moreover the results showed negative correlation between fungal isolates and soil salinity (r=0.202) while the number of species of fungal society was positively correlated ( r= 0.109).
The hemolytic activity of 30 species in vitro using blood agar culture:18 species showed variable capabilities in hemolysis. Aspergillus fumigatus was with more capability than other examined fungi in tested blood which took 3 days only while this ability of other species was varied from 4 to 12 days .

EFFECTS OF ENAMINOTHIONES COMPOUNDS ON THE DERMATOPHYES AND YEAST ISOLATES IN VITRO

Aqeel Abbas Kareem; Jawad K ml hi in; Adnan H AL-Hamdani

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 209-215

Three enaminothione compounds namely 5,5- Dimethyl -3 N (N,N-Diethyl) phenylamino -2- Cyclohexane -1- thione ; 5, 5- Dimethyl -3N (4- Bromophenyl) amino -2- Cyclohexane -1- thione ; 5,5- Dimethyl -3N-phenyl) amino -2- Cyclohexane -1- thione were prepared and their U.V. and I.R. spectra were measured. The inhibitory activity of these compounds were tested by disc diffusion method against pathogenic fungi ( dermatophytes and yeast infections ) in vitro . Results revealed that synthesized compounds have an inhibitory effect against the tested fungal isolates .

In Vitro Study For The Effect Of Cinnamon Oil On Multi-Drug Resistant Staphylococcus aureus And Proteus mirabilis Strains

Israa Kitab Al -Yasiri

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 216-226

The study was carried out to assess the effect of cinnamon oil on multi-drug resistant (MDR) strains of Staphylococcus aureus and Proteus mirabilis isolated from patient infected with otitis media. 50 specimens were collected at AL-Hakeem Teaching Hospital in AL-Najaf governorate, 20 isolates were found to be Staphylococcus spp. and Proteus spp. on further studying for the species level only six of these isolates were found to be multi-drug resistant Staphylococcus aureus and Proteus mirabilis. The results of antibiotic sensitivity testing showed that most of these isolates were highly resistant (resistance percentage was 40-90%) for the used antibiotics. The antimicrobial effect of cinnamon oil on these
isolates was tested via performing Disk Diffusion Method, Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) tests. The results showed a similarity in the antimicrobial actions between this oil and Ciprofloxacin antibiotic . The study concluded that Cinnamon Oil could be used as an effective antimicrobial even in case of difficult treated MDR Staphylococcus aureus and Proteus mirabilis.

RESISTANCE AND SENSITIVITY PATTERN OF CLINICAL ISOLATES OF STAPHYLOCOCCUS AUREUS AGAINST GENTAMYCIN, CO-TRIMETHOPRIM, AMOXICILLIN AND CEFALEXIN IN AL-NAJAF AL-ASHREF

ADEL.H.SHEEH

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 227-235

Staphylococcus aureus one of the most common pathogen that cause a wide range of infection started by simple skin infection and end by septicemias and high possibility of death .we try to study the sensitivity and resistance pattern of staphylococcus aureus against Gentamycin, Cotrimethoprim, Amoxicillin and Cefalexin .A 55 isolates of staphylococcus aureus obtained from urine, pleural fluid, joint aspiration, ear, skin, and pus, of indoor and outdoor patient in
AL-SADER teaching hospital, AL-NAJAF AL-ASHREF, IRAQ. From a period extended between 9-1-2006 - ---8-3-2007.And each isolate was tested for these 4 antibacterial drug , and we see that Gentamycin show the highest percentage of sensitivity by staphylococcus aureus (34.83%) while Amoxicillin show the highest percentage of resistance by staphylococcus aureus ( 30%).

IMMUNOLOGICAL STUDY OF Toxocara canis IN DOGS AND MICE AT BASRAH CITY

A. A. A. Al-Azizz; Suzan; A. H. H. Awad

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 236-252

Sixty-five sera samples were collected from stray dogs in Basrah which included 31 dogs infected with T. canis, 21 dogs infected with cestodes, while 13 dogs were infected with other nematodes then T. canis. The antibody concentration for eggs crude antigen (ECA) and adult crude antigen (ACA), adult purified antigen (APA) was evaluated using IHAT test for monitoring toxocariasis in dogs. The sensitivity of the above antigens was 64.5, 86.2 and 93.5%, respectively, while the specificity was 84.4, 93.8 and 100 %, respectively. Furthermore, the predictive values were 80.0, 92.6 and 100 %, respectively, while, the likelihood ratio was 4.5, 14.3 and ∞ for the above antigens.
No cross reaction was detected between the above three antigens and the infection with cestodes.
A total of 48 sera samples from mice experimentally infected with 2nd stage larvae of T. canis with two doses (250 and 500 larvae) at 1, 2, 3 weeks and 2, 4, 6 days post-infection. IHAT was used with larval excretory/ secretory and tegumental larval antigens. The total sensitivity was 91.66% and 83.33% for E/S, while it was 58.33 and 50% for TES, respectively. The specificity was 100% for E/S and TES at both doses, respectively. The predictive value for E/S was 91.66% in dose (500) larvae and 95.83% at second dose (250, larvae). It was found that in case of TES antigen, the predictive value was 75% and 79.16% at both doses (500 and 250 larvae, respectively).
There was no cross-reaction between the above larval antigens and the infection with cestodes and nematodes

Azithromycin: Is it a favorable alternative therapeutic option against salmonella species

Sameer Hasen Abood; Manal Mohammad Kadhim; Bassim Irheim Mohammed

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 253-258

Background: For decades chloramphenicol has been highly effective against S. typhi and S.paratyphyi . However the known hematological side effects of chloramphenicol and the widespread emergence of multiple drug resistance (MDR) to S. typhi has necessitated the search for other therapeutic options .
Aim of study: To compare between azithromycin and chloramphenicol as antimicrobial drugs for isolated salmonella species

Materials and Methods: 65 isolates of salmonella spp. was collected by performing blood culture and stool culture for suspected patients with history of typhoid fever and diarrhea at Maternity and Child teaching Hospital in Diwaniyah city. For each isolates antimicrobial susceptibilities for azothromycin and chloramphenicol were determined by Disk diffusion methods.In addition, a broth dilution tests for azithromycin were performed by using serial dilution of concentrations ranging from 4- 32 mg liter to record the minimal inhibitory concentration (MIC) for azithromycin .
Results: The isolated salmonella species are high susceptible of to azithromycin in comparison to chloramphenicol with lower MIC.
Conclusion: though it needs further clinical studies, azithromycin seems to be a suitable therapeutic option for the treatment of typhoid fever in children as well as in adult.

Assessment of Smart Check Recombinant Test in Diagnosis of Pulmonary Tuberculosis In Al-Najaf Al-Ashraf Governorate

Abdul Razzak Yassin Abdullah

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 259-265

This cross sectional study was undertaken to evaluate the Smart Check Recombinant TB test which is a rapid membrane based screening test to detect the presence of antibodies to active M. tuberculosis (Serological test, which is used for the first time in Al -Najaf Al-Ashraf governorate) in screening for pulmonary tuberculosis as a rapid diagnostic test of pulmonary tuberculosis, in comparison with sputum smear microscopy depending on the (findings and clinical judgment). Patients involved were those who attend at Respiratory Chest Diseases Center in AL– Najaf AL-Ashraf Governorate. Fifty suspected patients, within the age groups 12 - 70 years old who were referred from primary health care centers, hospitals, and private clinics, between1/5/2006to31/6/2006. From 50 cases 7 (14 %) were diagnosed as pulmonary tuberculosis by Smart Check test and 43 (86%) all patients were negative, by direct sputum smear microscopy .
Chi-square had been applied to test, the level of significance when alpha < 0.05 and indicated there was high significant association.

Posttraumatic stress disorder in students exposed to trauma

Qabas Nether; Atyaf sarhan; Ali Al-Hamzawi

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 266-271

A total of (300) students of secondary school in Diwaniya province were interviewed to assess the psychological impact of the trauma. A post traumatic stress checklist was used for the interview. The result of this study showed that the majority of the students suffer from post traumatic stress disorder.
Key word:-Posttraumatic stress disorder (PTSD).

Management of three cases of pyometrocolpos due to distal vaginal atresia in infants

Mohammed J. Aboud

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 272-282

Children with pyometrocolpos due to distal vaginal atresia may present as acutely ill, with severe obstructive uropathy and septicemia. In such patients the clinical course is markedly improved by urgent drainage of the infected cystic mass, and a temporary drainage procedure is required to allow local findings of infection to subside before definitive surgery. We present a 3 cases one at 2 months and two cases at 4- months of age old females with pyometrocolpos two of them with the above-mentioned clinical course and one of them with typical presentation of Mayer Rokitansky Kuster Houser syndrome (MRKH syndrome) ( is characterized by Mullerian duct structures agenesis, vaginal atresia being
the commonest variant) ,presenting and having association of anorectal malformation, Mullerian duct agenesis and renal anomaly , all received urgent laparotomy and drainage through the upper abdominal wall transverse incision (was performed in spite of the high risks of complex drainage procedures and general anesthesia). This drainage did result in dramatically improved clinical status, and findings of local inflammation resolved within 4-6 weeks, which facilitated a later successful definitive surgical procedure.

Comparative study of cancer in AL-Diwanihyia governerate before and after the war 2003

Rabab hajoal; Aqeel reheem AL- Barqawi

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 283-296

The aim Of the study to compare the occurrence of cancer in Al Diwaniya city before and after the war 2003.
The result show increase the number of carcinoma cases from the year 1992 – 2006 the number of cases was doubled from the years 1992 – 2002 and the doubled nine times after the years 2003 in comparison to the years 1989 – 1992 the study show most of cases are lived in the urbon area .

A study of Hyponatremia in Hospitalized Patients

Aqeel reheem AL- Barqawi

Al-Qadisiah Medical Journal, 2007, Volume 3, Issue 1, Pages 297-307

A study of hyponatremia in adult hospital inpatients over 16 yrs old admitted to the medical department of Al-Diwania teaching Hospital from the 1st of June 2006 to 10th of November 2006, showed that (50) out of (720) patients studied had serum sodium concentration below 135 meq/L.
Twenty five patients (50%) were on diuretics and 16 patients (32%) had heart failure.
The commonest type of hyponatremia was euvolemic hyponatremia (52%)
Forty one pts. (82%) had symptoms attributable to the hyponatremia.
The aim of the study was to determine the incidence, clinical characteristics, and causes of hyponatremia in medical wards of the Al-Diwaniah teaching Hospital.