Al-Qadisiah Medical Journal

Abstract

This study was designed to assess some hematological and biochemical changes related to the acute myocardial infarction patients ,since the levels of these constituents are very important for the health care team to know how the body is responding to the different therapies that being provided and this will help the medical staff for proper management with less morbidity and mortality .
The study proceeded from March /2010 to August / 2010. There are 48 patients with acute myocardial infarction (AMI) and healthy subjects of both sexes.
The patients were diagnosed by specialist physicians by using positive troponin I tests, typical chest pain and changes in ECG . A total number of 26 patients ; 14 males and 12 females and 22 of healthy control subjects ; 12 males and 10 females.The ages of subjects ranged between 40 to 60 years. Those patients were admitted to the cardiac care unit (CCU) in Marjan Teaching hospital in Hilla city. A history and physical examination were obtained and laboratory tests were performed in all subjects during first 3 days of attack .
Concerning the hematological parameters , it was found that white blood cells(WBCs) count and erythrocyte sedimentation rate (ESR) of male and female AMI patients showed significant increase(P<0.001) in comparison with healthy controls.
Regarding the biochemical parameters ,it was found significant increase(P<0.001) in total serum triglycerides, total cholesterol, LDL and VLDL (P<0.01)in male and female AMI patients in comparison with healthy controls .While HDL significantly decrease(P<0.001) in both male and female patients in comparison with that of control. Serum magnesium and zinc concentration of both male and female AMI patients showed significant decrease(in male , P<0.05 ; P<0.01 and in female , P<0.01; P<0.01 , respectively) in comparison with control. While ,serum calcium, blood urea and serum creatinine in patients with AMI of both males and females are significantly increased (P<0.001) (exception in calcium, female at P<0.01 ) in comparison with the controls groups.